QUINOMOX EYE DROPS 5 ML
Moxifloxacin hydrochloride
Moxifloxacin 0.5% eye drops
Composition
Moxifloxacin hydrochloride
equivalent to moxifloxacin 5 mg.
Sterile aqueous base q.s.
Dosage form
Ophthalmic Solution (Eye drops)
Description
Moxifloxacin is an 8-methoxy fluoroquinolone with a diazabicyclononyl ring at the
C7 position. The antibacterial action of moxifloxacin results from inhibition of
the topoisomerase II (DNA gyrase) and topoisomerase IV. DNA gyrase is an essential
enzyme that is involved in the replication, transcription and repair of bacterial
DNA. Topoisomerase IV is an enzyme known to play a key role in the partitioning
of the chromosomal DNA during bacterial cell division.
Indications
Moxifloxacin ophthalmic solution is indicated for the treatment of bacterial conjunctivitis.
Contraindications
Moxifloxacin ophthalmic solution is contraindicated in patients with a history of
hypersensitivity to moxifloxacin, to other quinolones, or to any of the components
in this medication.
Warnings & precautions
As with other anti-infectives, prolonged use may result in overgrowth of non-susceptible
organisms, including fungi. If superinfection occurs, discontinue use and institute
alternative therapy. Whenever clinical judgment dictates, the patient should be
examined with the aid of magnification, such as slit-lamp biomicroscopy, and, where
appropriate, fluorescein staining. Patients should be advised not to wear contact
lenses if they have signs and symptoms of bacterial conjunctivitis.
Lactation
Moxifloxacin has not been measured in human milk, although it can be presumed to
be excreted in human milk. Caution should be exercised when moxifloxacin solution
is administered to a lactating female.
Adverse effects
The most frequently reported ocular undesirable effects were conjunctivitis, decreased
visual acuity, dry eye, keratitis, ocular discomfort, ocular hyperemia, ocular pain,
ocular pruritus, sub-conjunctival hemorrhage, and tearing. These events occurred
in approximately 1-6% of patients.
Storage
Store in a cool dry place. Protect from light.
Presentation
Quinomox
eye drops is available in sterile plastic bottle of 5 ml.
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