OLFRESH TABLET ( WELL BALANCED NUTRIENTS FOR NORMAL EYE FUNCTION )

Omega 3 powder                                   500 mg.

Vitamin –C ( Ascorbic Acid )                   40 mg.

Vitamin – A ( Beta-carotine )              6000 I.U.

Vitamin – E ( Powder )                             25 mg.

Niacin ( Vit B3 )                                          16 mg.

Lutein                                                          10 mg.

Zinc                                                                7 mg.

Manganese                                                2.3 mg.

Zeaxanthin                                                    2 mg.

Riboflovin ( Vit B2 )                                  1.3 mg.

Vitamin B6                                                 1.3 mg.

Thiamin ( Vit B1 )                                      1.2 mg.

Calcium                                                          1 mg.

Copper                                                        0.9 mg.

Folic Acid ( Vit B9 )                                 240 mcg.

Selenium                                                    34 mcg.

Vitamin B12                                              2.4 mcg.

It also contains the following excipients: Microcrystalline cellulose, calcium silicate, hydroxypropyl methylcellulose, silicon dioxide, purified stearic acid and magnesium stearate.

Coating: Purified water, titanium dioxide, hydroxypropyl methylcellulose, hydroxypropyl cellulose, polyethylene glycol, caramel color, polysorbate 80, montan wax, ethyl vanillin, diacetylated monoglycerides and xanthan powder.

Multivitamins with minerals ; Used as dietary supplements.

Mechanism of action

Increased TNF-a in the lacrimal gland increases lacrimal gland apoptosis ( programmed cell death). Increased apoptosis contributes to decreased in tear production & increase in tearfilm osmolarity that drives dry eye ocular surface disorder. 

EPA & DHA elongated with enzymes produces anti inflammatory prostaglandin E3 (PGE 3) & leukotrienes B5 (LTB 5)

EPA blocks the gene expression of pro inflammatory cytokines tumor necrosis factor alpha (TNF a), interleukin-1a (IL-1a), interleukin-1b (IL-1), proteoglycan degrading enzymes & cyclo oxygenase and thus reduces the imflammation. 

Meibomian glands use essential fatty acids to synthesize oil. Omega 3 fatty acids clears & thins the meibomian gland secretions & stimulates tear secretions. 

Indications 

Olfresh : Nutritional supplement for the eye. Vitamin and mineral deficiencies due to age, unbalanced diet, prolonged exposure to natural or artificial light, mental fatigue and stress, pollution, and tobacco.

Olfresh: Advanced antioxidant supplement of vitamins and mineral salts, that are involved in cellular protection against the degenerative action of free radicals. The vitamins and mineral salts of Olfresh are also essential for optimal cell metabolism.

In particular, Olfresh combines the vitamins and mineral salts necessary for maximizing vision and health of the eye. The vitamins and mineral salts of Olfresh are associated with the reduction in the risk of age-associated macular degeneration.

They protect the eye from developing cataracts, are coadjuvants against changes in corneal epithelium with opacity of the cornea (xerophthalmia), and protect against deficient adjustment of vision to darkness.

Olfresh is also indicated in the case of hypovitaminosis, states where there is a greater need for vitamins and minerals, eg, stressful situations, physical exercise, unvaried diet, ageing, treatment with antibiotics, infections, febrile states, diets, states with loss of appetite, chronic alcoholism and exposure to sunlight.

OLFRESH is also indicated for chronic dry eyes.

DOSAGE & ADMINISTRATIONS

Olfresh: 1 Tablet with water in the morning for at least 1 month. To be renewed when necessary.

Olfresh: 1 tablet/day by the oral route with water and a meal.

CONTRAINDICATIONS

Olfresh: Known hypersensitivity to any of the ingredients of Olfresh.

Severe impairment of renal function or the presence of renal calculi; with other preparations containing Vitamin A.

Vitamin E should not be taken when there is an alteration in prothrombin activity and the clotting time.

Smokers should not use multivitamin preparations containing ß-carotene.

SPECIAL PRECAUTIONS 

Olfresh: Discontinue treatment in case of hypersensitivity.

Effects on the Ability to Drive or Operate Machinery: Cases of interference with the ability to drive or operate machines are not known.

Use in pregnancy & lactation: Multivitamin preparations should be used during pregnancy and lactation only as directed by a physician.

ADVERSE DRUG REACTION 

Olfresh: Hypersensitivity and diarrhea have been reported with Olfresh.

Patients receiving long-term ß-carotene therapy experience a yellow or orange skin pigmentation because of accumulation of the drug in the skin.

Vitamin C is usually nontoxic; however, nausea, vomiting, heartburn, abdominal cramps, fatigue, flushing, headache, insomnia and sleepiness have been reported.

DRUG INTERACTION 

Olfresh: Due to the presence of zinc, chelation with tetracyclins may occur. Concurrent use of penicillamine may reduce the absorption of zinc.

STORAGE 

Olfresh: Store away from heat.

Olfresh: Store below 25°C, in a cool and dry place.

Olfresh: tab (coated) 10  in alu alu pack